The skin barrier is broadly composed of two elements—a physical barrier mostly localised in
the epidermis, and an immune barrier localised in both the dermis and epidermis. These two …

Suppressing inflammation has been the primary focus of therapies in autoimmune rheumatic
diseases (AIRDs), including rheumatoid arthritis and systemic lupus erythematosus …

Atopic dermatitis (AD) affects up to 20% of children and adults worldwide. To gain a deeper
understanding of the pathophysiology of AD, we conducted a large-scale transcriptomic …

Background Hyperactivity of the IL-23/IL-17 axis is central to plaque psoriasis pathogenesis.
Secukinumab, a fully human mAb that selectively inhibits IL-17A, is approved for treatment of …

Psoriasis is an immune-mediated inflammatory disease of the skin. Previous studies
including ours have shown that IL-17A plays a major role in its pathogenesis; however, its …

Psoriasis (PSO) is a common skin disease that affects about 1%–3% of the general
population. It is a great medical, social and economic burden since PSO is associated with …

IL-17 was discovered nearly 30 yr ago, but it has only been recently appreciated that a key
function of this cytokine is to orchestrate cellular and organismal metabolism. Indeed …

During the last decades, high-throughput assessment of gene expression in patient tissues
using microarray technology or RNA-Seq took center stage in clinical research. Insights into …

Retinoic acid–related orphan receptor γt (RORγt) functions as a ligand-dependent
transcription factor that regulates multiple proinflammatory genes and plays a critical role in …

Cholesterol and its metabolites are bioactive lipids that interact with and regulate the activity
of various proteins and signaling pathways that are implicated in the control of a variety of …