Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer

YQ Tan, YS Chiou, H Guo, S Zhang, X Huang… - NPJ Precision …, 2024 - nature.com
Aberrant activation of the PI3K/AKT signaling axis along with the sustained phosphorylation
of downstream BAD is associated with a poor outcome of TNBC. Herein, the phosphorylated …

Crystal structure, molecular mechanics and In silico analyses of piperizine derivative against human mammary carcinoma cells inhibition.

HK Kumar, S Ananda, V Keerthikumara… - IOP Conference …, 2024 - iopscience.iop.org
In the present study, the single crystal of novel piperazine derivative4-(2, 3-chlorophenyl)
piperazine-1-yl)(2-hydroxyphenyl) methanone (KDM) is grown by using the solvent …

Uloga ćelijske senescencije indukovane onkogenima u malignoj transformaciji i progresiji tumora dojke

D Jovanović - Универзитет у Крагујевцу, 2022 - nardus.mpn.gov.rs
Uprkos značaju pojedinih prognostičkih faktora, njihova tačnost u proceni ishoda i
određivanju strategija lečenja obolelih od karcinoma dojke je ograničena. Stoga bi …