Overcoming TGFβ-mediated immune evasion in cancer
Transforming growth factor-β (TGFβ) signalling controls multiple cell fate decisions during
development and tissue homeostasis; hence, dysregulation of this pathway can drive …
development and tissue homeostasis; hence, dysregulation of this pathway can drive …
TGF-β Regulation of T Cells
WJ Chen - Annual review of immunology, 2023 - annualreviews.org
Transforming growth factor β (TGF-β) is a key cytokine regulating the development,
activation, proliferation, differentiation, and death of T cells. In CD4+ T cells, TGF-β maintains …
activation, proliferation, differentiation, and death of T cells. In CD4+ T cells, TGF-β maintains …
Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has high relapse and low 5-year survival rates. Single-cell
profiling in relapsed HCC may aid in the design of effective anticancer therapies, including …
profiling in relapsed HCC may aid in the design of effective anticancer therapies, including …
EBV miRNAs BART11 and BART17-3p promote immune escape through the enhancer-mediated transcription of PD-L1
J Wang, J Ge, Y Wang, F Xiong, J Guo, X Jiang… - Nature …, 2022 - nature.com
Epstein-Barr virus (EBV) is reportedly the first identified human tumor virus, and is closely
related to the occurrence and development of nasopharyngeal carcinoma (NPC), gastric …
related to the occurrence and development of nasopharyngeal carcinoma (NPC), gastric …
Challenges and new technologies in adoptive cell therapy
P Zhang, G Zhang, X Wan - Journal of Hematology & Oncology, 2023 - Springer
Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …
Identification of an immune-specific class of hepatocellular carcinoma, based on molecular features
Background & aims Agents that induce an immune response against tumors by altering T-
cell regulation have increased survival times of patients with advanced-stage tumors, such …
cell regulation have increased survival times of patients with advanced-stage tumors, such …
Molecular and cellular insights into T cell exhaustion
EJ Wherry, M Kurachi - Nature reviews immunology, 2015 - nature.com
In chronic infections and cancer, T cells are exposed to persistent antigen and/or
inflammatory signals. This scenario is often associated with the deterioration of T cell …
inflammatory signals. This scenario is often associated with the deterioration of T cell …
[HTML][HTML] TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures
The immune checkpoint receptor PD-1 on T follicular helper (Tfh) cells promotes Tfh: B cell
interactions and appropriate positioning within tissues. Here, we examined the impact of …
interactions and appropriate positioning within tissues. Here, we examined the impact of …
T-cell exhaustion in chronic infections: reversing the state of exhaustion and reinvigorating optimal protective immune responses
T-cell exhaustion is a phenomenon of dysfunction or physical elimination of antigen-specific
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
TGF-β signaling: from tissue fibrosis to tumor microenvironment
JYF Chung, MKK Chan, JSF Li, ASW Chan… - International Journal of …, 2021 - mdpi.com
Transforming growth factor-β (TGF-β) signaling triggers diverse biological actions in
inflammatory diseases. In tissue fibrosis, it acts as a key pathogenic regulator for promoting …
inflammatory diseases. In tissue fibrosis, it acts as a key pathogenic regulator for promoting …