Free radicals are generated in the brain, as well as in other organs, and their production is
proportional to the brain activity. Due to its low antioxidant capacity, the brain is particularly …

CNS injuries such as trauma, stroke, viral infection, febrile seizures, status epilepticus
occurring either in infancy or during a lifetime are considered common risk factors for …

Background: Neuronal hyperexcitability and excessive production of free radicals have been
implicated in the pathogenesis of a considerable range of neurological disorders, including …

Epilepsy is characterized by recurrent seizures due to a perturbed balance between
glutamate and GABA neurotransmission. Our goal is to reveal the molecular mechanisms of …

Huntington's disease (HD) is caused by an abnormal expanded polyglutamine (polyQ)
repeat in the huntingtin protein. Insulin-like growth factor-1 acting through the prosurvival …

Epilepsy is a complex neurological disorder manifested by recurrent episodes of convulsive
seizures, loss of consciousness, and sensory disturbances. Pentylenetetrazole (PTZ) …

Epilepsy is a neurological disorder which occurs due to excessive firing of excitatory
neurons in specific region of brain and associated with cognitive impairment and …

Background Neuroinflammation, oxidative stress and mitochondrial dysfunction play a
significant role to explain the pathophysiology of epilepsy. Neuroinflammation through …

Brain cyclooxygenases (COX), the rate-limiting enzyme in prostaglandin synthesis, is rapidly
and transiently induced by convulsions in hippocampal and cortical neurons. Previous …

Purpose Atorvastatin (ATV) is widely used for the treatment of dyslipidemias. Recent
evidence has shown that ATV has protection effects against seizures. However, the effect of …