Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …

Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

Abstract Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling is one of the most important intracellular pathways, which can be considered as a …

Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …

PURPOSE Patients with indolent non-Hodgkin lymphoma typically respond well to first-line
immunochemotherapy. At relapse, single-agent rituximab is commonly administered. Data …

Follicular lymphoma (FL) is a systemic neoplasm of the lymphoid tissue displaying germinal
centre (GC) B cell differentiation. FL represents~ 5% of all haematological neoplasms and …

Purpose Phosphatidylinositol 3-kinase (PI3K) signaling is critical for the proliferation and
survival of malignant B cells. Copanlisib, a pan-class I PI3K inhibitor with predominant …

The Central Role of PI3K in Cell Signaling Phosphatidylinositol 3-kinase (PI3K) is involved
in multiple cell processes, including insulin signaling, cell growth, immunity, and brain …

Background Copanlisib, an intravenous pan-class I PI3K inhibitor, showed efficacy and
safety as monotherapy in patients with relapsed or refractory indolent non-Hodgkin …