Although the molecular effectors of apoptotic cell death have been largely annotated over
the past 30 years, leading to a strong biological understanding of this process and its …

Renal ischemia-reperfusion (IR) contributes to the development of ischemic acute renal
failure (ARF). Multi-factorial processes are involved in the development and progression of …

High‐mobility group box 1 (HMGB1) is an abundant chromatin‐associated nuclear protein
and released into the extracellular milieu during liver ischemia‐reperfusion (I/R), signaling …

In ischemia/reperfusion (I/R) injury increased intracellular Ca2+ and production of reactive
oxygen species (ROS) may cause cell death by intrinsic apoptotic pathways or by necrosis …

Recently, erythropoietin was shown to have both hematopoietic as well as tissue‐protective
properties. Erythropoietin (EPO) had a protective effect in animal models of cerebral …

Nicotinamide mononucleotide adenylyltransferease (NMNAT), a rate-limiting enzyme
present in all organisms, reversibly catalyzes the important step in the biosynthesis of NAD …

Abstract Poly (ADP-ribose) polymerases (PARPs) catalyze the post-translational
modification of proteins with poly (ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2 …

Background and purpose: Activation of poly (ADP‐ribose) polymerase (PARP) is deleterious
during cerebral ischemia. We assessed the influence of PARP activation induced by …

Hepatic ischemia-reperfusion (HIR) injury is a common pathophysiological process in many
clinical settings. This study was designed to compare the protective role of octreotide …

The regular intake of tomatoes or its products has been associated with a reduced risk of
chronic diseases and these effects have been mainly attributed to lycopene. Here, we …