Glucosinolates from cruciferous vegetables and their potential role in chronic disease: Investigating the preclinical and clinical evidence

EL Connolly, M Sim, N Travica, W Marx… - Frontiers in …, 2021 - frontiersin.org
An increasing body of evidence highlights the strong potential for a diet rich in fruit and
vegetables to delay, and often prevent, the onset of chronic diseases, including …

Efficacy of sulforaphane in neurodegenerative diseases

G Schepici, P Bramanti, E Mazzon - International journal of molecular …, 2020 - mdpi.com
Sulforaphane (SFN) is a phytocompound belonging to the isothiocyanate family. Although it
was also found in seeds and mature plants, SFN is mainly present in sprouts of many …

Sulforaphane reduces obesity by reversing leptin resistance

I Çakır, P Lining Pan, CK Hadley, A El-Gamal… - Elife, 2022 - elifesciences.org
The ascending prevalence of obesity in recent decades is commonly associated with
soaring morbidity and mortality rates, resulting in increased health-care costs and …

Targeting epigenetics: A novel promise for Alzheimer's disease treatment

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Sulforaphane-role in aging and neurodegeneration

R Santín-Márquez, A Alarcón-Aguilar… - Geroscience, 2019 - Springer
In the last several years, numerous molecules derived from plants and vegetables have
been tested for their antioxidant, anti-inflammatory, and anti-aging properties. One of them is …

The cannabinoids, CBDA and THCA, rescue memory deficits and reduce amyloid-beta and tau pathology in an Alzheimer's disease-like mouse model

J Kim, P Choi, YT Park, T Kim, J Ham… - International journal of …, 2023 - mdpi.com
Most studies related to hemp are focused on Cannabidiol (CBD) and Tetrahydrocannabinol
(THC); however, up to 120 types of phytocannabinoids are present in hemp. Hemp leaves …

Role of oxidative stress in the pathogenesis of amyotrophic lateral sclerosis: antioxidant metalloenzymes and therapeutic strategies

P Hemerková, M Vališ - Biomolecules, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) affects motor neurons in the cerebral cortex, brainstem
and spinal cord and leads to death due to respiratory failure within three to five years …

Pre-clinical neuroprotective evidences and plausible mechanisms of Sulforaphane in Alzheimer's disease

J Kim - International journal of molecular sciences, 2021 - mdpi.com
Sulforaphane, a potent dietary bioactive agent obtainable from cruciferous vegetables, has
been extensively studied for its effects in disease prevention and therapy. Sulforaphane …

Role of Nrf2 in synaptic plasticity and memory in Alzheimer's disease

DA Davies, A Adlimoghaddam, BC Albensi - Cells, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that
reduces oxidative stress. When reactive oxygen species (ROS) or reactive nitrogen species …

The histone modifications of neuronal plasticity

H Geng, H Chen, H Wang, L Wang - Neural Plasticity, 2021 - Wiley Online Library
Nucleosomes composed of histone octamer and DNA are the basic structural unit in the
eukaryote chromosome. Under the stimulation of various factors, histones will undergo …