Chromosome aberrations, in particular translocations and their corresponding gene fusions,
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …

The discovery of recurrent gene fusions in a majority of prostate cancers has important
clinical and biological implications in the study of common epithelial tumours. Gene fusion …

Abstract Characterization of the prostate cancer transcriptome and genome has identified
chromosomal rearrangements and copy number gains and losses, including ETS gene …

Chromosomal rearrangements fusing the androgen-regulated gene TMPRSS2 to the
oncogenic ETS transcription factor ERG occur in approximately 50% of prostate cancers, but …

TMPRSS2-ERG gene fusions are the predominant molecular subtype of prostate cancer.
Here, we explored the role of TMPRSS2-ERG gene fusion product using in vitro and in vivo …

Recently, we identified recurrent gene fusions involving the 5′ untranslated region of the
androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family …

Prostate cancer is a common heterogeneous disease, and most patients diagnosed in the
post prostate-specific antigen (PSA) era present with clinically localized disease, the …

Prostate cancer (PCA) is one of the most prevalent cancers and a major leading cause of
morbidity and mortality in the Western world. The TMPRSS2-ERG fusion was recently …

CONTEXT: In 2005, fusions between the androgen-regulated transmembrane protease
serine 2 gene, TMPRSS2, and E twenty-six (ETS) transcription factors were discovered in …

BACKGROUND Prostate cancer (PCa) exhibits significant differences in prevalence and
mortality among different ethnic groups. The underlying genetics is not well understood …