Heat tolerance and exertional heat stroke (EHS) are rare health conditions that have been described and characterised but have never been genetically solved. Knowledge of the role …
R Gill, M Liu, G Sun, A Furey, T Spector, P Rahman… - BMC genomics, 2024 - Springer
Background Genomic heterozygosity has been shown to confer a health advantage in humans and play a protective role in complex diseases. Given osteoarthritis (OA) is a highly …
J Mendes, AR Guimarães, JM Ribeiro… - Orthodontics & …, 2024 - Wiley Online Library
Background Non‐syndromic orofacial cleft (NSOC) is a complex phenotype, involving multiple genetic and environmental factors. Association studies exploring the genetic …
A classic population genetic prediction is that alleles experiencing directional selection should swiftly traverse allele frequency space, leaving detectable reductions in genetic …
A Hamdan Almaeen… - Pharmacogenomics and …, 2021 - Taylor & Francis
Purpose This is the first cross-sectional study studying the changes in haematological indicators of the response to recombinant human erythropoietin (rHuEPO) therapy in chronic …
Background. To investigate the association of glutathione s‐transferase omega 2 (GSTO2)(142N> D) and transforming growth factor‐β1 (TGF‐β1)(869T> C) gene …
BACKGROUND: AMPK has pivotal roles in glucose and lipid metabolism, including AMPKa2, which PRKAA2 encodes. Metformin as an anti-hyperglycemia agent acts through …
A classic population genetic prediction is that alleles experiencing directional selection should swiftly traverse allele frequency space, leaving detectable reductions in genetic …
MJ Catarata, R Medeiros, MJ Oliveira, A Pêgo… - Cancers, 2020 - mdpi.com
Simple Summary The presence of polymorphic gene variants in the human genome provides extensive genetic (and eventually phenotypic) variation affecting both normal …