The use of natural compounds as an alternative to synthetic molecules has become a
significant subject of interest in recent decades. Stilbenoids are a group of phenolic …

The innate immune system is the first line of host defense, and it is capable of resisting both
exogenous pathogenic challenges and endogenous danger signals via different pattern …

The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans,
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …

Alzheimer's disease (AD) is characterized by progressive neurodegeneration, memory loss,
and cognitive impairment leading to dementia and death. The blood-brain barrier (BBB) …

Ion channels play a crucial role in a wide range of biological processes, including cell cycle
regulation and cancer progression. In particular, the transient receptor potential (TRP) family …

Similar to their pivotal roles in nervous system development, neurons have emerged as
critical regulators of cancer initiation, maintenance, and progression. Focusing on nervous …

Introduction: Glioblastoma (GBM) is the most common invasive brain tumor composed of
diverse cell types with poor prognosis. The highly complex tumor microenvironment (TME) …

Tuberous sclerosis complex (TSC) is a rare multisystem disorder caused by heterozygous
loss-of-function pathogenic variants in the tumour suppressor genes TSC1 and TSC2 …

Oral squamous cell carcinoma (OSCC) is a common cancer with poor prognosis. Transient
Receptor Potential Ankyrin 1 (TRPA1) and Vanilloid 1 (TRPV1) receptors are non-selective …

Ion channels provide the basis for the nervous system's intrinsic electrical activity. Neuronal
excitability is a characteristic property of neurons and is critical for all functions of the …