Immunomodulation by endothelial cells—partnering up with the immune system?

J Amersfoort, G Eelen, P Carmeliet - Nature Reviews Immunology, 2022 - nature.com
Blood vessel endothelial cells (ECs) have long been known to modulate inflammation by
regulating immune cell trafficking, activation status and function. However, whether the …

The glycolytic process in endothelial cells and its implications

SWS Leung, Y Shi - Acta Pharmacologica Sinica, 2022 - nature.com
Endothelial cells play an obligatory role in regulating local vascular tone and maintaining
homeostasis in vascular biology. Cell metabolism, converting food to energy in organisms, is …

[HTML][HTML] Nucleo-cytosolic acetyl-CoA drives tumor immune evasion by regulating PD-L1 in melanoma

H Wang, X Yi, X Wang, Y Yang, H Zhang, H Wang… - Cell Reports, 2024 - cell.com
Acetyl coenzyme A (acetyl-CoA), a versatile central metabolite, plays a critical role in various
metabolic processes and protein acetylation. While its impact on tumor cell properties is well …

Dysfunctional bone marrow endothelial progenitor cells are involved in patients with myelodysplastic syndromes

T Xing, ZS Lyu, CW Duan, HY Zhao, SQ Tang… - Journal of Translational …, 2022 - Springer
Background Myelodysplastic syndromes (MDS) are a group of heterogeneous myeloid
clonal disorders characterized by ineffective haematopoiesis and immune deregulation …

Targeted inhibition of the immunoproteasome blocks endothelial MHC class II antigen presentation to CD4+ T cells in chronic liver injury

Y Zhang, X Yang, T Bi, X Wu, L Wang, Y Ren… - International …, 2022 - Elsevier
Chronic or overwhelming liver injury is frequently associated with fibrosis, which is the main
histological characteristic of non-alcoholic steatohepatitis (NASH). Currently, there is no …

Sourcing cells for in vitro models of human vascular barriers of inflammation

MC McCloskey, VZ Zhang, SD Ahmad… - Frontiers in Medical …, 2022 - frontiersin.org
The vascular system plays a critical role in the progression and resolution of inflammation.
The contributions of the vascular endothelium to these processes, however, vary with tissue …

Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate receptor 1 in proangiogenic glomerular endothelial cells under diabetic condition

B Yu, K Shen, T Li, J Li, M Meng… - … of Physiology-Cell …, 2023 - journals.physiology.org
Glomerular angiogenesis is a characteristic feature of diabetic nephropathy (DN). Enhanced
glycolysis plays a crucial role in angiogenesis. The present study was designed to …

Periodontitis deteriorates renal fibrosis and macrophage infiltration in rats with chronic kidney disease

YS Lee, AR Kim, YE Jeon, EJ Bak, YJ Yoo - Oral Diseases, 2024 - Wiley Online Library
Objective The objective of this study was to examine the effect of periodontitis on renal
function and morphology in rats with or without nephrectomy (Nx)‐induced chronic kidney …

Subtotal Nephrectomy as a Model of Chronic Kidney Disease: A Systematic Review.

PN Cahyawati, BK Satriyasa - Indian Journal of Public …, 2021 - search.ebscohost.com
Abstract Background: Subtotal nephrectomy (5/6 nephrectomy) is one of the most widely
used animal models for modifying chronic kidney disease. Animal models of kidney disease …