Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation
in tissue architecture and regenerative demands, SCs often follow similar paradigms in …

Muscle stem cells, or satellite cells, are required for skeletal muscle maintenance, growth,
and repair. Following satellite cell activation, several factors drive asymmetric cell division to …

Stem-Cell Research and Clinical Application Stem cells have been the focus of hope, hype,
and a great deal of research. But what exactly is a stem cell, and what are its uses? This …

Single-cell RNA-sequencing (scRNA-seq) facilitates the unbiased reconstruction of
multicellular tissue systems in health and disease. Here, we present a curated scRNA-seq …

Stem cell niches are composed of dynamic microenvironments that support stem cells over a
lifetime. The emerging niche is distinct from the adult because its main role is to support the …

The developmental trajectory of human skeletal myogenesis and the transition between
progenitor and stem cell states are unclear. We used single-cell RNA sequencing to profile …

Lack of dystrophin causes muscle degeneration, which is exacerbated by chronic
inflammation and reduced regenerative capacity of muscle stem cells in Duchenne Muscular …

Human pluripotent stem cells (hPSCs) can be directed to differentiate into skeletal muscle
progenitor cells (SMPCs). However, the myogenicity of hPSC-SMPCs relative to human fetal …

Although heterogeneity is recognized within the murine satellite cell pool, a comprehensive
understanding of distinct subpopulations and their functional relevance in human satellite …

Muscle stem cells, the engine of muscle repair, are affected in myotonic dystrophy type 1
(DM1); however, the underlying molecular mechanism and the impact on the disease …