Why most clinical research is not useful

JPA Ioannidis - PLoS medicine, 2016 - journals.plos.org
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Plasmonic meniscus lenses

JA Riley, N Healy, V Pacheco-Peña - Scientific reports, 2022 - nature.com
Controlling and manipulating the propagation of surface plasmons has become a field of
intense research given their potential in a wide range of applications, such as plasmonic …

Trends in global clinical trial registration: an analysis of numbers of registered clinical trials in different parts of the world from 2004 to 2013

RF Viergever, K Li - BMJ open, 2015 - bmjopen.bmj.com
Objectives To analyse developments (and their causes) in the number and proportion of
clinical trials that were registered in different parts of the world after the International …

A systematic review of the processes used to link clinical trial registrations to their published results

R Bashir, FT Bourgeois, AG Dunn - Systematic reviews, 2017 - Springer
Background Studies measuring the completeness and consistency of trial registration and
reporting rely on linking registries with bibliographic databases. In this systematic review, we …

Call to improve transparency of trials of non-regulated interventions

R Dal-Ré, MB Bracken, JPA Ioannidis - Bmj, 2015 - bmj.com
The public and clinicians require transparent, quality evidence for all interventions. Trials of
non-regulated interventions are common, and efforts to improve their registration and …

The unknown prevalence of postrandomization bias in 15 physical therapy journals: a methods review

SP Riley, BT Swanson, SM Shaffer, SF Sawyer… - Journal of Orthopaedic & …, 2021 - jospt.org
Objectives To determine the prevalence of prospective clinical trial registration and
postrandomization bias in published musculoskeletal physical therapy randomized clinical …

Evaluation of journal registration policies and prospective registration of randomized clinical trials of nonregulated health care interventions

M Azar, KE Riehm, N Saadat, T Sanchez… - JAMA Internal …, 2019 - jamanetwork.com
Importance Many interventions that are important to the health care of patients are not
subject to regulation by the US Food and Drug Administration (FDA) or comparable …

[HTML][HTML] Inadequate use and regulation of interventions against publication bias decreases their effectiveness: a systematic review

K Thaler, C Kien, B Nussbaumer, MG Van Noord… - Journal of clinical …, 2015 - Elsevier
Objectives To determine the effectiveness of interventions designed to prevent or reduce
publication and related biases. Study Design and Setting We searched multiple databases …

A mapping of 115,000 randomized trials revealed a mismatch between research effort and health needs in non–high-income regions

I Atal, L Trinquart, P Ravaud, R Porcher - Journal of clinical epidemiology, 2018 - Elsevier
Background Concerns exist as to whether the allocation of resources in clinical research is
aligned with public health needs. We evaluated the alignment between the effort of clinical …

Manual therapy for non-radicular cervical spine related impairments: establishing a 'Trustworthy'living systematic review and meta-analysis

SP Riley, SM Shaffer, DW Flowers… - Journal of Manual & …, 2023 - Taylor & Francis
Objectives To establish a 'trustworthy'living systematic review (SR) with a meta-analysis of
manual therapy for treating non-radicular cervical impairments. Design SR with meta …