Animal studies have shown that oxidative stress and renal tubulointerstitial inflammation are
associated with, and have major roles in, the pathogenesis of hypertension. This view is …

Nitroxides can undergo one-or two-electron reduction reactions to hydroxylamines or
oxammonium cations, respectively, which themselves are interconvertible, thereby providing …

Omega-3 fatty acid docosahexaenoic acid is converted to potent resolvins (Rv) and protectin
D1 (PD1), two newly identified families of natural mediators of resolution of inflammation. We …

Hypertension and hypertension-associated ESRD are epidemic in society. The mechanisms
responsible for renal progression in mild to moderate hypertension and those groups most …

Role of hypoxia in the pathogenesis of renal disease The kidney shows a remarkable
discrepancy between blood supply and oxygenation. Despite high blood flow and oxygen …

Obesity and type 2 diabetes are associated with nonalcoholic steatohepatitis (NASH), but an
obese/diabetic animal model that mimics human NASH remains undefined. We examined …

Significance: Renal oxidative stress can be a cause, a consequence, or more often a
potentiating factor for hypertension. Increased reactive oxygen species (ROS) in the kidney …

We analyzed renal cell cancer incidence patterns in the United States and reviewed recent
epidemiologic evidence with regard to environmental and host genetic determinants of renal …

Hypertensive kidney disease classically entails nephroangiosclerosis and hyalinosis with
glomerular damage. However, in recent years, several evidences showed that high blood …

The presence of macrophages in inflamed glomeruli of rat kidney correlates with
proliferation and apoptosis of resident glomerular mesangial cells. We assessed the …