Natural Ingredients of Transdermal Drug Delivery Systems as Permeation Enhancers of Active Substances through the Stratum Corneum

N Schafer, R Balwierz, P Biernat… - Molecular …, 2023 - ACS Publications
In recent years, significant progress has been made in transdermal drug delivery systems,
but there is still a search for enhancers that can improve the absorption of active substances …

Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends

BE Polat, D Hart, R Langer, D Blankschtein - Journal of controlled release, 2011 - Elsevier
The use of ultrasound for the delivery of drugs to, or through, the skin is commonly known as
sonophoresis or phonophoresis. The use of therapeutic and high frequencies of ultrasound …

[HTML][HTML] Enhancement of transdermal drug delivery via synergistic action of chemicals

P Karande, S Mitragotri - Biochimica et Biophysica Acta (BBA) …, 2009 - Elsevier
Transdermal drug delivery is an attractive alternative to conventional techniques for
administration of systemic therapeutics. One challenge in designing transdermal drug …

Transdermal iontophoresis: combination strategies to improve transdermal iontophoretic drug delivery

Y Wang, R Thakur, Q Fan, B Michniak - European Journal of Pharmaceutics …, 2005 - Elsevier
For several decades, there has been interest in using the skin as a port of entry into the body
for the systemic delivery of therapeutic agents. However, the upper layer of the skin, the …

Mechanical properties of human stratum corneum: effects of temperature, hydration, and chemical treatment

KS Wu, WW Van Osdol, RH Dauskardt - Biomaterials, 2006 - Elsevier
An in vitro mechanics approach to quantify the intercellular delamination energy and
mechanical behavior of isolated human stratum corneum (SC) in a direction perpendicular …

Two‐photon microscopy of deep intravital tissues and its merits in clinical research

BG Wang, K König, KJ Halbhuber - Journal of microscopy, 2010 - Wiley Online Library
Multiphoton excitation laser scanning microscopy, relying on the simultaneous absorption of
two or more photons by a molecule, is one of the most exciting recent developments in …

Optical methods for non-invasive determination of skin penetration: current trends, advances, possibilities, prospects, and translation into in vivo human studies

ME Darvin - Pharmaceutics, 2023 - mdpi.com
Information on the penetration depth, pathways, metabolization, storage of vehicles, active
pharmaceutical ingredients (APIs), and functional cosmetic ingredients (FCIs) of topically …

A multiphase microscopic diffusion model for stratum corneum permeability. I. Formulation, solution, and illustrative results for representative compounds

TF Wang, GB Kasting, JM Nitsche - Journal of pharmaceutical sciences, 2006 - Elsevier
A two-dimensional microscopic transport model of the stratum corneum (SC) incorporating
corneocytes of varying hydration and permeability embedded in an anisotropic lipid matrix is …

Studying the effectiveness of penetration enhancers to deliver retinol through the stratum cornum by in vivo confocal Raman spectroscopy

M Mélot, PDA Pudney, AM Williamson… - Journal of controlled …, 2009 - Elsevier
The purpose of this study is to monitor in vivo the effect of chemical penetration enhancers
on the delivery of trans-retinol into human skin. Chemical penetration enhancers reversibly …

A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability …

TF Wang, GB Kasting, JM Nitsche - Journal of pharmaceutical sciences, 2007 - Elsevier
The full parameterization for the stratum corneum biphasic microtransport model presented
previously in this Journal [95: 620–648 (2006)] is developed through a combination of …