The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy

J Zhang, X Huang, H Wang, X Liu, T Zhang… - Stem cell research & …, 2015 - Springer
Mesenchymal stem cells (MSCs) are ideal for cell-based therapy in various inflammatory
diseases because of their immunosuppressive and tissue repair properties. Moreover, their …

MSCs: delivery routes and engraftment, cell‐targeting strategies, and immune modulation

TJ Kean, P Lin, AI Caplan, JE Dennis - Stem cells international, 2013 - Wiley Online Library
Mesenchymal stem cells (MSCs) are currently being widely investigated both in the lab and
in clinical trials for multiple disease states. The differentiation, trophic, and …

Concise review: the surface markers and identity of human mesenchymal stem cells

FJ Lv, RS Tuan, KMC Cheung, VYL Leung - Stem cells, 2014 - academic.oup.com
The concept of mesenchymal stem cells (MSCs) is becoming increasingly obscure due to
the recent findings of heterogeneous populations with different levels of stemness within …

Mesenchymal stem cell-mediated effects of tumor support or suppression

KJ Rhee, JI Lee, YW Eom - International journal of molecular sciences, 2015 - mdpi.com
Mesenchymal stem cells (MSCs) can exhibit a marked tropism towards site of tumors. Many
studies have reported that tumor progression and metastasis increase by MSCs. In contrast …

The role of integrin α6 (CD49f) in stem cells: more than a conserved biomarker

PH Krebsbach, LG Villa-Diaz - Stem cells and development, 2017 - liebertpub.com
Stem cells have the capacity for self-renewal and differentiation into specialized cells that
form and repopulated all tissues and organs, from conception to adult life. Depending on …

Mesenchymal stem cells: A living carrier for active tumor-targeted delivery

T Zhang, R Lin, H Wu, X Jiang, J Gao - Advanced Drug Delivery Reviews, 2022 - Elsevier
The strategy of using mesenchymal stem cells (MSCs) as a living carrier for active delivery of
therapeutic agents targeting tumor sites has been attempted in a wide range of studies to …

The dark side of the force–constraints and complications of cell therapies for stroke

J Boltze, A Arnold, P Walczak, J Jolkkonen… - Frontiers in …, 2015 - frontiersin.org
Cell therapies are increasingly recognized as a promising option to augment the limited
therapeutic arsenal available to fight ischemic stroke. During the last two decades …

Effects of different mesenchymal stromal cell sources and delivery routes in experimental emphysema

MA Antunes, SC Abreu, FF Cruz, AC Teixeira… - Respiratory …, 2014 - Springer
We sought to assess whether the effects of mesenchymal stromal cells (MSC) on lung
inflammation and remodeling in experimental emphysema would differ according to MSC …

[HTML][HTML] Mesenchymal stem cells as carriers for systemic delivery of oncolytic viruses

A Hadryś, A Sochanik, G McFadden… - European journal of …, 2020 - Elsevier
Progress in genetic engineering led to the emergence of some viruses as potent anticancer
therapeutics. These oncolytic viruses combine self-amplification with dual antitumor action …

Current understanding of the therapeutic benefits of mesenchymal stem cells in acute respiratory distress syndrome

M Lopes-Pacheco, C Robba, PRM Rocco… - Cell biology and …, 2020 - Springer
The acute respiratory distress syndrome (ARDS) is a multifaceted lung disorder in which no
specific therapeutic intervention is able to effectively improve clinical outcomes. Despite an …