Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Digestive cancers are the leading cause of cancer-related death worldwide and have high
risks of morbidity and mortality. Histone methylation, which is mediated mainly by lysine …

Although immunotherapy has revolutionized cancer care, patients with pancreatic ductal
adenocarcinoma (PDA) rarely respond to these treatments, a failure that is attributed to poor …

Background Endothelial cell (EC) injury accelerates the progression of diabetic
macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible …

Background: Bone is a frequent site of metastases from breast cancer, but existing
therapeutic options are not satisfactory. Although osteoblasts have active roles in cancer …

The ever-growing perception of cancer stem cells (CSCs) as a plastic state rather than a
hardwired defined entity has evolved our understanding of the functional and biological …

Obesity increases the risk for cardiovascular diseases and induces cardiomyopathy. Chronic
inflammation plays a significant role in obesity-induced cardiomyopathy and may provide …

Lung adenocarcinoma is the most common form of lung cancer, accounting for 60% of non-
small cell lung cancer (NSCLC) cases in Asian patients. Importantly, nearly half of these …

Surgical resection, when combined with chemotherapy, has been shown to significantly
improve the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) …

Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1
histone demethylases that promote gene expression. The KDM3 subfamily primarily consists …