Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on
hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain …

CD8+ tissue-resident memory T (T RM) cells play crucial roles in defense against infections
and cancer and have been implicated in autoimmune diseases such as psoriasis. In mice …

Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the
body. Although TRM cells in various organs rely on common transcriptional networks to …

Background TGFβ signaling plays a pleotropic role in tumor biology, promoting tumor
proliferation, invasion and metastasis, and escape from immune surveillance. Inhibiting …

Although imatinib induces marked responses in patients with chronic myeloid leukemia
(CML), resistance is increasingly problematic, and treatment options for imatinib-resistant or …

Tissue-specific uptake and sufficient biodistribution are central goals in drug development.
Crossing the blood–brain barrier (BBB) represents a major challenge in delivering …

PD-1/PD-L1 blockade therapies provide notable clinical benefits for patients with advanced
cancers, but the factors influencing the effectiveness of the treatment remain incompletely …

Studies have shown that mesenchymal stem cells (MSCs) have low immunogenicity and
immune regulation. Human umbilical cord Wharton's jelly provides a new source for MSCs …

There is sufficient evidence to suggest that tumor growth elicits specific immune responses,
including CD8+ and CD4+ T cell responses that may delay tumor growth and could …

TGF-β1 deficient mice develop multifocal inflammatory autoimmune disease and serve as a
valuable animal model of autoimmunity. Transgenic expression of a dominant negative form …