Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

B Niu, K Liao, Y Zhou, T Wen, G Quan, X Pan, C Wu - Biomaterials, 2021 - Elsevier
Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …

Biomedicine meets Fenton chemistry

Z Tang, P Zhao, H Wang, Y Liu, W Bu - Chemical reviews, 2021 - ACS Publications
Since the first connection between Fenton chemistry and biomedicine, numerous studies
have been presented in this field. Comprehensive presentation of the guidance from Fenton …

Inorganic nanomaterials with rapid clearance for biomedical applications

X Wang, X Zhong, J Li, Z Liu, L Cheng - Chemical Society Reviews, 2021 - pubs.rsc.org
Inorganic nanomaterials that have inherently exceptional physicochemical properties (eg,
catalytic, optical, thermal, electrical, or magnetic performance) that can provide desirable …

Multi-enzyme co-expressed dual-atom nanozymes induce cascade immunogenic ferroptosis via activating interferon-γ and targeting arachidonic acid metabolism

Y Liu, R Niu, R Deng, S Song, Y Wang… - Journal of the American …, 2023 - ACS Publications
Immunotherapy is currently the most promising treatment strategy for long-term tumor
regression. However, current cancer immunotherapy shows low response rates due to …

Solutions to the drawbacks of photothermal and photodynamic cancer therapy

X Deng, Z Shao, Y Zhao - Advanced Science, 2021 - Wiley Online Library
Phototherapy such as photothermal therapy and photodynamic therapy in cancer treatment
has been developed quickly over the past few years for its noninvasive nature and high …

A nonferrous ferroptosis-like strategy for antioxidant inhibition–synergized nanocatalytic tumor therapeutics

C Wu, Z Liu, Z Chen, D Xu, L Chen, H Lin, J Shi - Science advances, 2021 - science.org
Ferroptosis, an emerging type of cell death found in the past decades, features specifically
lipid peroxidation during the cell death process commonly by iron accumulation …

Glutathione-depleting nanomedicines for synergistic cancer therapy

X Cheng, HD Xu, HH Ran, G Liang, FG Wu - ACS nano, 2021 - ACS Publications
Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …

Multienzyme-like reactivity cooperatively impairs glutathione peroxidase 4 and ferroptosis suppressor protein 1 pathways in triple-negative breast cancer for sensitized …

K Li, C Lin, M Li, K Xu, Y He, Y Mao, L Lu, W Geng… - ACS …, 2022 - ACS Publications
Ferroptosis is a recently discovered route of regulated cell death that offers the opportunities
for the treatment of chemotherapy-resistant tumor indications, but its efficacy can be affected …

Copper-based metal–organic frameworks for biomedical applications

JE Cun, X Fan, Q Pan, W Gao, K Luo, B He… - Advances in Colloid and …, 2022 - Elsevier
Metal–organic frameworks (MOFs) are a class of important porous, crystalline materials
composed of metal ions (clusters) and organic ligands. Owing to the unique redox chemistry …

Tumor Microenvironment Stimuli‐Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon‐Dot–Cu2+ Nanoassemblies

S Sun, Q Chen, Z Tang, C Liu, Z Li, A Wu… - Angewandte …, 2020 - Wiley Online Library
A method is developed to fabricate tumor microenvironment (TME) stimuli‐responsive
nanoplatform for fluorescence (FL) imaging and synergistic cancer therapy via assembling …