The main features of the triple helical structure of collagen were deduced in the mid-1950s
from fibre X-ray diffraction of tendons. Yet, the resulting models only could offer an average …

Protein structure prediction is a way to bridge the sequence-structure gap, one of the main
challenges in computational biology and chemistry. Predicting any protein's accurate …

Targeting protein kinases is an important strategy for intervention in cancer. Inhibitors are
directed at the active conformation or a variety of inactive conformations. While attempts …

Monkeypox virus (MPXV) outbreaks have been reported in various countries worldwide;
however, there is no specific vaccine against MPXV. In this study, therefore, we employed …

This research aimed to compare and characterize the physicochemical properties and
interaction mechanism of zein and anthocyanins (ACNs) from experimental and theoretical …

Introduction Hybrid drug design has developed as a prime method for the development of
novel anticancer therapies that can theoretically solve much of the pharmacokinetic …

The three-dimensional structure of medium-sized cyclic peptides accounts for their
biological activity and other important physiochemical properties. Despite significant …

Synonymous codons translate into chemically identical amino acids. Once considered
inconsequential to the formation of the protein product, there is evidence to suggest that …

The naturally inspired multitarget-directed ligands (PC01–PC10 and PD01–PD26) were
synthesized from piperine for the management of Alzheimer's disease (AD). The compound …

SARS-CoV-2 is the deadly virus behind COVID-19, the disease that went on to ravage the
world and caused the biggest pandemic 21st century has witnessed so far. On the face of …