Hyperdiploidy is the largest genetic entity B-cell precursor acute lymphoblastic leukemia in
children. The diagnostic hallmark of its two variants that will be discussed in detail herein is …

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. ALL arises
from the malignant transformation of progenitor B-and T-cells in the bone marrow into …

Background Although aberrant DNA methylation has been observed previously in acute
lymphoblastic leukemia (ALL), the patterns of differential methylation have not been …

Despite an increase in survival for children with acute lymphoblastic leukemia (ALL), the
outcome after relapse is poor. To understand the genetic events that contribute to relapse …

DNA methylation is tightly regulated during development and is stably maintained in healthy
cells. In contrast, cancer cells are commonly characterized by a global loss of DNA …

Acute lymphoblastic leukemia (ALL) is the commonest childhood malignancy and is
characterized by recurring structural genetic alterations. Previous studies of DNA …

Objective: The purpose of this study was to determine the global patterns of aberrant DNA
methylation in thyroid cancer. Research Design and Methods: We have used DNA …

The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list
of necessary mitochondrial processes is steadily growing. Here, we summarize the current …

DNA methylation is an important epigenetic modification for genomic regulation in higher
organisms that plays a crucial role in the initiation and progression of diseases. The …

Studies of childhood leukemia and the potential etiologic role of genetic variation in folate
metabolism have produced conflicting findings and have often been based on small …