Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

The prevalence and cost of chronic pain is a major physical and mental health care problem
in the United States today. As a result, there has been a recent explosion of research on …

Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

Tumor necrosis factor alpha (TNF-α) was discovered more than a century ago, and its known
roles have extended from within the immune system to include a neuro-inflammatory domain …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Animal models are pivotal for understanding the mechanism of neuropathic pain and
development of effective therapy for its optimal management. A battery of neuropathic pain …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …

Postherpetic neuralgia (PHN) is a common and often devastatingly painful condition. It is
also one of the most extensively investigated of the neuropathic pains. Patients with PHN …

Neuropathic pain is defined aspain initiated or caused by a primary lesion or dysfunction in
the nervous system'. 94 The spectrum of neuropathic pain covers a variety of disease states …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …