Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Advanced age is a strong independent predictor for death, disability, and morbidity in
patients with structural heart disease. With the projected increase in the elderly population …

Growing evidence exists that ATP-sensitive mitochondrial potassium channels (MitoKATP
channel) are a major contributor to the cardiac protection against ischemia. Given the …

Protein kinase C (PKC) is involved in the second messenger signaling cascade during
ischemic and Ca2+ preconditioning. Given that the pharmacological activation of …

We tested the hypothesis that elevation of [Ca2+] i during ischemic preconditioning (IPC)
stimulates protein kinase C (PKC), which confers the protection against the ischemic injury …

We tested the hypothesis whether calcium preconditioning (CPC) reduces reoxygenation
injury by inhibiting mitochondrial permeability transition (MPT). Cultured myocytes were …

Decreased oxygen availability impairs cellular energy production and, without a coordinated
and matched decrease in energy consumption, cellular and whole organism death rapidly …

Endogenous adenosine is produced by the heart during ischemia-reperfusion as a natural
cardioprotectant. The benefits of this local protective mechanism can be harnessed by …

We tested the hypothesis that elevation of [Ca2+] i during Ca2+ preconditioning (CPC) is a
strong activator of protein kinase C (PKC) and confers unique protection against ischemic …

Background Ischemia preconditioning (IPC) ameliorates coronary no-reflow induced by
ischemia/reperfusion (I/R) injury, and pericytes play an important role in microvascular …