Cholesterol modulates the bilayer structure of biological membranes in multiple ways. It
changes the fluidity, thickness, compressibility, water penetration and intrinsic curvature of …

Membrane fusion is a key process in all living organisms that contributes to a variety of
biological processes including viral infection, cell fertilization, as well as intracellular …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Most functions of eukaryotic cells are controlled by cellular membranes, which are not static
entities but undergo frequent budding, fission, fusion, and sculpting reactions collectively …

Lipids are the most abundant organic compounds in the brain. The brain has a unique
lipidome, and changes in lipid concentration, organization, and metabolism are associated …

Insulin is produced by pancreatic β-cells, and once released to the blood, the hormone
stimulates glucose uptake and suppresses glucose production. Defects in both the …

The clustering of proteins and lipids in distinct microdomains is emerging as an important
principle for the spatial patterning of biological membranes. Such domain formation can be …

Abstract PI (4, 5) P 2 participates directly in priming and possibly in fusion steps of Ca 2+-
triggered vesicle exocytosis. High concentration nanodomains of PI (4, 5) P 2 reside on the …

Syntaxin1A is organized in nanoclusters that are critical for the docking and priming of
secretory vesicles from neurosecretory cells. Whether and how these nanoclusters are …

SNAREs are undoubtedly one of the core elements of synaptic transmission. Contrary to the
well characterized function of their SNARE domains bringing the plasma and vesicular …