ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-
inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G …

Glioblastoma multiforme (GBM), a highly invasive and incurable tumor, is the humans'
foremost, commonest, and deadliest brain cancer. As in other cancers, distinct combinations …

Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the
most lethal of childhood cancers. Palliative radiotherapy is the only established treatment …

ONC201 is the first member of the imipridone family of anticancer drugs to enter the clinic for
the treatment of diverse solid and hematologic cancers. A subset of pediatric and adult …

Purpose: Novel therapeutic targets are critical to unravel for the most common primary brain
tumor in adults, glioblastoma (GBM). We have identified a novel synthetic lethal interaction …

Acute myeloid leukemia (AML) is a heterogeneous disease with variable presentation,
molecular phenotype, and cytogenetic abnormalities and has seen very little improvement in …

Background Glioblastoma represents a brain tumor with a notoriously poor prognosis. First-
line therapy may include adjunctive Tumor Treating Fields (TTFields) which are electric …

Glioblastoma WHO IV (GBM), the most common primary brain tumor in adults, is a
heterogenous malignancy that displays a reprogrammed metabolism with various fuel …

Radiotherapy failure and poor tumor prognosis are primarily attributed to radioresistance.
Improving the curative effect of radiotherapy and delaying cancer progression have become …

Glucose, the primary substrate for ATP synthesis, is catabolized during glycolysis to
generate ATP and precursors for the synthesis of other vital biomolecules. Opportunistic …