[HTML][HTML] Emerging concepts of miRNA therapeutics: from cells to clinic

C Diener, A Keller, E Meese - Trends in Genetics, 2022 - cell.com
MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …

[HTML][HTML] Molecular biomarkers in cancer

VK Sarhadi, G Armengol - Biomolecules, 2022 - mdpi.com
Molecular cancer biomarkers are any measurable molecular indicator of risk of cancer,
occurrence of cancer, or patient outcome. They may include germline or somatic genetic …

[HTML][HTML] The evolving role of investigative toxicology in the pharmaceutical industry

F Pognan, M Beilmann, H Boonen, A Czich… - Nature reviews drug …, 2023 - nature.com
For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …

[HTML][HTML] Extracellular miRNAs: from biomarkers to mediators of physiology and disease

MA Mori, RG Ludwig, R Garcia-Martin, BB Brandão… - Cell metabolism, 2019 - cell.com
miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …

[HTML][HTML] Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome

CR Kahn, G Wang, KY Lee - The Journal of clinical …, 2019 - Am Soc Clin Investig
Over the past decade, great progress has been made in understanding the complexity of
adipose tissue biology and its role in metabolism. This includes new insights into the …

An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

K Saliminejad, HR Khorram Khorshid… - Journal of cellular …, 2019 - Wiley Online Library
MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in
posttranscriptional regulation of gene expression. They are powerful regulators of various …

An estimate of the total number of true human miRNAs

J Alles, T Fehlmann, U Fischer, C Backes… - Nucleic acids …, 2019 - academic.oup.com
While the number of human miRNA candidates continuously increases, only a few of them
are completely characterized and experimentally validated. Toward determining the total …

Reexamining assumptions about miRNA-guided gene silencing

A Kilikevicius, G Meister, DR Corey - Nucleic acids research, 2022 - academic.oup.com
MicroRNAs (miRNAs) are short endogenously expressed RNAs that have the potential to
regulate the expression of any RNA. This potential has led to the publication of several …

[HTML][HTML] Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

AL Cardoso, A Fernandes, JA Aguilar-Pimentel… - Ageing research …, 2018 - Elsevier
Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

An integrated expression atlas of miRNAs and their promoters in human and mouse

D De Rie, I Abugessaisa, T Alam, E Arner, P Arner… - Nature …, 2017 - nature.com
MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As
part of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) …