CK2 (formerly termed “casein kinase 2”) is a ubiquitous, highly pleiotropic and constitutively
active Ser/Thr protein kinase whose implication in neoplasia, cell survival, and virus …

Monoclonal antibodies (mAbs) are being increasingly used in cancer therapy owing to their
ability to recognize specifically cancer cells and to activate complement-and cell-mediated …

Complement is a central part of the immune system that has developed as a first defense
against non-self cells. Neoplastic transformation is accompanied by an increased capacity of …

More than 46 years ago, Burnett and Kennedy first described protein kinase CK2 (formerly
known as casein kinase 2) in liver extracts. Since then, protein kinase CK2 has been …

Complement-mediated cell death is caused by C5b-9, the membrane attack complex (MAC)
composed of the five complement proteins C5b, C6, C7, C8, and C9. Assembly of the C5b-9 …

Clinical and experimental studies have suggested that complement may play a role in tumor
cytotoxicity. However, the efficiency of complement-mediated tumor cell lysis is hampered by …

The complement system is composed of soluble blood plasma proteins and cell membrane
proteins. A major function of the soluble complement proteins is to bind to and destroy …

Nucleated cells employ several strategies to evade killing by homologous complement. We
studied complement resistance in the human carcinoma cell lines (CA) T47D (mammary) …

The interactions of cancer cells with components of the complement system are highly
complex, leading to an outcome that is either favorable or detrimental to cancer cells …

Protein kinase CK2 is a highly conserved, pleiotropic, protein serine/threonine kinase that is
essential for life in eukaryotes. CK2 has been implicated in diverse cellular processes such …