Signal transduction with the diatomic radical nitric oxide (NO) is involved in a number of
important physiological processes, including smooth muscle relaxation and …

Over the past 25 years, the role of nitric oxide (NO) in biology has evolvedfrom being
recognized as an environmental pollutant to an endogenously produced substance involved …

Since the discoveries that have verified nitric oxide (NO) as an endogenously produced cell
signaling molecule, research surrounding its production and mechanisms of action have …

Endothelial dysfunction, as observed in hypertension and atherosclerosis, is associated with
a reduction in the bioavailability of endothelium-derived nitric oxide (NO). We tested the …

NO-sensitive guanylyl cyclase (GC) acts as the effector molecule for NO and therefore plays
a key role in the NO/cGMP signalling cascade. Besides the long known GC isoform (α1β1) …

Soluble guanylate cyclase (sGC) is an important component of the NO signaling pathway.
Human sGC isoforms α1, α2, and β1 show differential mRNA tissue distributions. α1 and β1 …

Soluble guanylate cyclase (sGC), a heterodimeric (α/β) haem protein that converts GTP to
the second messenger cGMP, functions as the receptor for nitric oxide (NO) and …

Guanylyl cyclases (GCs) are enzymes that convert guanosine-5′-triphosphate (GTP) to
cyclic guanosine-3′, 5′-monophosphate (cGMP). The second messenger cGMP …

Introduction Cattle temperament is an important factor that affects the profitability of beef
cattle enterprises, due to its relationship with productivity traits, animal welfare and labor …

Soon after the discovery of cAMP, cGMP was detected in urine (Ashman et al. 1963), and,
later on, was shown to be formed in practically all cells and tissues (Hardman and …