Age-related cognitive decline is the major cause of concern due to its 70% more incidence
than dementia cases worldwide. Moreover, aging is also the major risk factor of Alzheimer's …

The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and
cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a …

Some of the intrinsically disordered proteins and protein regions are promiscuous
interactors that are involved in one-to-many and many-to-one binding. Several studies have …

Localized translation plays a crucial role in synaptic plasticity and memory consolidation.
However, it has not been possible to follow the dynamics of memory-associated mRNAs in …

Activity-regulated cytoskeleton-associated protein (Arc) is one of the most important
regulators of cognitive functions in the brain regions. As a hub protein, Arc plays different …

Delayed neuronal death is associated with neurological deficits and mortality after traumatic
brain injury (TBI), where post-synaptic density (PSD) proteins are thought to play key roles …

In recent years, with the discovery and research of lactate-specific receptor HCAR1
(hydroxycarboxylic acid receptor 1), lactate is not only as a product of Glycolysis in …

SUMOylation is a post‐translational modification that regulates protein signalling and
complex formation by adjusting the conformation or protein–protein interactions of the …

Patients with irritable bowel syndrome (IBS) show pain hypersensitivity and smooth muscle
hypercontractility in response to colorectal distension (CRD). Synaptic plasticity, a key …

Arc, also known as Arg3. 1, is an activity-dependent immediate–early gene product that
plays essential roles in memory consolidation. A pool of Arc is located in the postsynaptic …