Alternative erythropoietin receptors in the nervous system

D Ostrowski, R Heinrich - Journal of clinical medicine, 2018 - mdpi.com
In addition to its regulatory function in the formation of red blood cells (erythropoiesis) in
vertebrates, Erythropoietin (Epo) contributes to beneficial functions in a variety of non …

Acetylcholinesterase promotes apoptosis in insect neurons

DY Knorr, NS Georges, S Pauls, R Heinrich - Apoptosis, 2020 - Springer
Apoptosis plays a major role in development, tissue renewal and the progression of
degenerative diseases. Studies on various types of mammalian cells reported a pro …

Эритропоэтин и его биологическая роль

ОН Варламова, ОД Червяковская - Медицина: теория и практика, 2019 - cyberleninka.ru
В обзоре представлены данные о истории открытия эритропоэтина (ЭПО), его синтезе
и биологической роли. Продемонстрировано, что эритропоэтин не только является …

The insect ortholog of the human orphan cytokine receptor CRLF3 is a neuroprotective erythropoietin receptor

N Hahn, DY Knorr, J Liebig, L Wüstefeld… - Frontiers in Molecular …, 2017 - frontiersin.org
The cytokine erythropoietin (Epo) mediates various cell homeostatic responses to
environmental challenges and pathological insults. While stimulation of vertebrate …

The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor

DY Knorr, I Rodriguez Polo, HS Pies… - Frontiers in Molecular …, 2023 - frontiersin.org
The evolutionary conserved orphan cytokine receptor-like factor 3 (CRLF3) has been
implicated in human disease, vertebrate hematopoiesis and insect neuroprotection. While its …

The orphan cytokine receptor CRLF3 emerged with the origin of the nervous system and is a neuroprotective erythropoietin receptor in locusts

N Hahn, L Büschgens… - Frontiers in molecular …, 2019 - frontiersin.org
The orphan cytokine receptor-like factor 3 (CRLF3) was identified as a neuroprotective
erythropoietin receptor in locust neurons and emerged with the evolution of the eumetazoan …

Protection of insect neurons by erythropoietin/CRLF3-mediated regulation of pro-apoptotic acetylcholinesterase

DY Knorr, K Schneider, L Büschgens, J Förster… - Scientific Reports, 2022 - nature.com
Cytokine receptor-like factor 3 (CRLF3) is a conserved but largely uncharacterized orphan
cytokine receptor of eumetazoan animals. CRLF3-mediated neuroprotection in insects can …

EV-3, an endogenous human erythropoietin isoform with distinct functional relevance

C Bonnas, L Wüstefeld, D Winkler… - Scientific Reports, 2017 - nature.com
Generation of multiple mRNAs by alternative splicing is well known in the group of cytokines
and has recently been reported for the human erythropoietin (EPO) gene. Here, we focus on …

Erythropoietin-mediated neuroprotection in insects suggests a prevertebrate evolution of erythropoietin-like signaling

R Heinrich, V Günther, N Miljus - Vitamins and Hormones, 2017 - Elsevier
The cytokine erythropoietin (Epo) mediates protective and regenerative functions in
mammalian nervous systems via activation of poorly characterized receptors that differ from …

Developmental expression patterns of erythropoietin and its receptor in mouse brainstem respiratory regions

EMS Gasser, E Elliot-Portal, C Arias-Reyes… - Respiratory physiology …, 2019 - Elsevier
Erythropoietin (EPO) is a hypoxia-inducible hormone, classically known to enhance red
blood cell production upon binding its receptor (EPOR) present on the surface of the …