Both basal and glucose-stimulated insulin release occur primarily by insulin secretory
granule exocytosis from pancreatic β cells, and both are needed to maintain normoglycemia …

O-GlcNAcylation is a posttranslational modification ruled by the activity of a single pair of
enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). These two enzymes carry …

Although traditionally considered a glucose metabolism-associated modification, the O-
linked β-N-Acetylglucosamine (O-GlcNAc) regulatory system interacts extensively with lipids …

The importance of sexual dimorphism has been highlighted in recent years since the
National Institutes of Health's mandate on considering sex as a biological variable. Although …

O-Linked β-N-acetylglucosamine (O-GlcNAc) is an essential, dynamic monosaccharide post-
translational modification (PTM) found on serine and threonine residues of thousands of …

The emergence of genome-wide analyses to interrogate cellular DNA, RNA, and protein
content has revolutionized the study of control networks that mediate cellular homeostasis …

Background Diabetic kidney disease (DKD) is the leading cause of death in people with type
2 diabetes mellitus (T2DM). The main objective of this study is to find the potential …

Background/Objectives: During pregnancy, physiological changes in maternal circulating
glucose levels and its metabolism are essential to meet maternal and fetal energy demands …

O-GlcNAc transferase (OGT), a nutrient sensor sensitive to glucose flux, is highly expressed
in the pancreas. However, the role of OGT in the mitochondria of β-cells is unexplored. In …

O-linked-β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification (PTM) that is
actively added to and removed from thousands of intracellular proteins. As a PTM, O …