Re-emergence of chikungunya virus, a mosquito-transmitted pathogen, is of serious public
health concern. In the past 15 years, after decades of infrequent, sporadic outbreaks, the …

Mosquitoes live under the endless threat of infections from different kinds of pathogens such
as bacteria, parasites, and viruses. The mosquito defends itself by employing both physical …

Temperature is a strong driver of vector-borne disease transmission. Yet, for emerging
arboviruses we lack fundamental knowledge on the relationship between transmission and …

Highlights•Complex interactions occur within the mosquito holobiome that profoundly alter
the phenotype of the host.•Bacteria can enhance or suppress arbovirus transmission in …

Mosquito-borne diseases are associated with major global health burdens. Aedes spp. and
Culex spp. are primarily responsible for the transmission of the most medically important …

We have developed genetically modified Ae. aegypti mosquitoes that activate the conserved
antiviral JAK/STAT pathway in the fat body tissue, by overexpressing either the receptor …

Arthropod-borne viruses (arboviruses) pose a significant threat to global health, causing
human disease with increasing geographic range and severity. The recent availability of the …

Diseases caused by arthropod-borne viruses (arboviruses), such as Dengue, West Nile, and
Chikungunya, constitute a major global health burden and are increasing in incidence and …

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes chikungunya fever,
a severe, debilitating disease that often produces chronic arthralgia. Since 2004, CHIKV has …

Alphaviruses cause debilitating disease in humans and animals and are transmitted by
blood-feeding arthropods, typically mosquitoes. With a traditional focus on two models …