Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

SLC25 is a large family of nuclear-encoded transporters embedded in the inner
mitochondrial membrane and in a few cases other organelle membranes. The members of …

Mitochondrial permeability transition pore (MPTP) formation contributes to ischemia-
reperfusion injury in the heart and several degenerative diseases, including muscular …

Mitochondrial dysfunction is an underlying cause of ischemia-reperfusion injury. In
particular, ischemic injury induces dramatic increases in mitochondrial permeability, thereby …

Mitochondrial fusion and fission (mitochondrial dynamics) are homeostatic processes that
safeguard normal cellular function. This relationship is especially strong in tissues with …

Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange
of ADP and ATP across the mitochondrial inner membrane, plays an essential role in …

Mitochondria are implicated in many important cellular functions covering the whole life
cycle from mitochondrial biogenesis to cell death. Mitochondrial homeostasis is tightly …

Uncontrolled cell death is a fundamental cause of organ disease in humans. However,
despite the need for us to delineate the molecular machinery that underlies cardiomyocyte …

It is now clear that mitochondrial defects are associated with a plethora of clinical
phenotypes in man and mouse. This is the result of the mitochondria's central role in energy …

The adenosine nucleotide translocase (ANT) family of proteins are inner mitochondrial
membrane proteins involved in energy homeostasis and cell death. The primary function of …