Towards a deeper understanding of the vaginal microbiota

M France, M Alizadeh, S Brown, B Ma, J Ravel - Nature microbiology, 2022 - nature.com
The human vaginal microbiota is a critical determinant of vaginal health. These communities
live in close association with the vaginal epithelium and rely on host tissues for resources …

Interactions between microbiota and cervical epithelial, immune, and mucus barrier

M Dong, Y Dong, J Bai, H Li, X Ma, B Li… - Frontiers in cellular …, 2023 - frontiersin.org
The female reproductive tract harbours hundreds of bacterial species and produces
numerous metabolites. The uterine cervix is located between the upper and lower parts of …

The complex link between the female genital microbiota, genital infections, and inflammation

S Dabee, JAS Passmore, R Heffron… - Infection and …, 2021 - Am Soc Microbiol
The female genital tract microbiota is part of a complex ecosystem influenced by several
physiological, genetic, and behavioral factors. It is uniquely linked to a woman's mucosal …

The impact of sex on HIV immunopathogenesis and therapeutic interventions

E Mihealsick, A Word, EP Scully - The Journal of Clinical Investigation, 2024 - jci.org
Globally, the majority of people living with HIV are women or girls, but they have been a
minority of participants in clinical trials and observational studies of HIV. Despite this …

Lactobacillus-dominance and rapid stabilization of vaginal microbiota in combined oral contraceptive pill users examined through a longitudinal cohort study with …

S Tuddenham, P Gajer, AE Burke, C Murphy… - …, 2023 - thelancet.com
Background Bacterial vaginosis (BV), a condition in which vaginal Lactobacillus spp. are in
low abundance, is associated with vulvovaginal symptoms, obstetric outcomes and …

The association between lifestyle factors and the composition of the vaginal microbiota: a review

M Morsli, E Gimenez, C Magnan, F Salipante… - European Journal of …, 2024 - Springer
Purpose The vaginal microbiota offers valuable insights into women's sexual health and the
risk of developing sexually transmitted infections (STIs) and bacterial vaginosis. Despite the …

Impact of estrogen and progesterone on immune cells and host–pathogen interactions in the lower female reproductive tract

MK Collins, CR McCutcheon… - The Journal of …, 2022 - journals.aai.org
Microbial infections are a threat to women's reproductive health. Although reproductive
cycles and pregnancy are controlled by sex hormones, the impact of hormones on host …

Copper intrauterine device increases vaginal concentrations of inflammatory anaerobes and depletes lactobacilli compared to hormonal options in a randomized trial

BP Brown, C Feng, RF Tanko, SZ Jaumdally… - Nature …, 2023 - nature.com
Effective contraceptives are a global health imperative for reproductive-aged women.
However, there remains a lack of rigorous data regarding the effects of contraceptive options …

Role of the human vaginal microbiota in the regulation of inflammation and sexually transmitted infection acquisition: Contribution of the non-human primate model to …

C Adapen, L Réot, E Menu - Frontiers in Reproductive Health, 2022 - frontiersin.org
The human vaginal microbiota has a central role in the regulation of the female reproductive
tract (FRT) inflammation. Indeed, on one hand an optimal environment leading to a …

The relationship between pelvic floor functions and vaginal microbiota in 6–8 weeks postpartum women

Y Zhang, H Yang, L Lin, W Yang, G Xiong… - Frontiers in …, 2022 - frontiersin.org
The impairment of pelvic floor muscle functions and Lactobacillus-deficient vaginal
microbiota is common in postpartum women. However, few studies have explored the …