Stoichiometry and architecture of the human pyruvate dehydrogenase complex
The pyruvate dehydrogenase complex (PDHc) is a key megaenzyme linking glycolysis with
the citric acid cycle. In mammalian PDHc, dihydrolipoamide acetyltransferase (E2) and the …
the citric acid cycle. In mammalian PDHc, dihydrolipoamide acetyltransferase (E2) and the …
Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex
The pyruvate dehydrogenase complex (PDC) is a multienzyme complex central to aerobic
respiration, connecting glycolysis to mitochondrial oxidation of pyruvate. Similar to the E3 …
respiration, connecting glycolysis to mitochondrial oxidation of pyruvate. Similar to the E3 …
[HTML][HTML] The impact of sex differences on genomic research
S Oertelt-Prigione, E Mariman - The International Journal of Biochemistry & …, 2020 - Elsevier
Sex and gender differences affect all dimensions of human health ranging from the
biological basis of disease to therapeutic access, choice and response. Genomics research …
biological basis of disease to therapeutic access, choice and response. Genomics research …
Transcriptome analysis on key metabolic pathways in Rhodotorula mucilaginosa under Pb (II) stress
T Chen, Y Shi, C Peng, L Tang, Y Chen… - Applied and …, 2022 - Am Soc Microbiol
Rhodotorula mucilaginosa shows adaption to a broad range of Pb2+ stress. In this study,
three key pathways, ie, glycolysis (EMP), the tricarboxylic acid (TCA) cycle, and oxidative …
three key pathways, ie, glycolysis (EMP), the tricarboxylic acid (TCA) cycle, and oxidative …
Targeting the PDK/PDH axis to reverse metabolic abnormalities by structure-based virtual screening with in vitro and in vivo experiments
J Yue, J Xu, Y Yin, Y Shu, Y Li, T Li, Z Zou… - International Journal of …, 2024 - Elsevier
In humans and animals, the pyruvate dehydrogenase kinase (PDK) family proteins (PDKs 1–
4) are excessively activated in metabolic disorders such as obesity, diabetes, and cancer …
4) are excessively activated in metabolic disorders such as obesity, diabetes, and cancer …
Stratifying cellular metabolism during weight loss: an interplay of metabolism, metabolic flexibility and inflammation
Obesity is a global epidemic, contributing significantly to chronic non-communicable
diseases, such as type 2 diabetes mellitus, cardiovascular diseases and metabolic …
diseases, such as type 2 diabetes mellitus, cardiovascular diseases and metabolic …
Exploring diet-induced promoter hypomethylation and PDK4 overexpression: implications for type 2 diabetes mellitus
SED Putra, FM Humardani, LT Mulyanata… - Molecular Biology …, 2023 - Springer
Background Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by
limited metabolic flexibility in the body. Such limitation implicates the pyruvate …
limited metabolic flexibility in the body. Such limitation implicates the pyruvate …
RETRACTED ARTICLE: Alpha-Lipoic Acid Protects Against Doxorubicin-Induced Cardiotoxicity by Regulating Pyruvate Dehydrogenase Kinase 4
F Gong, J Jin, H Li, H Mao - Cardiovascular Toxicology, 2022 - Springer
As a widely used anti-tumor anthracycline, the accumulation of Doxorubicin (DOX) in body
causes irreparable cardiomyocyte damage and therefore is limited in clinical application …
causes irreparable cardiomyocyte damage and therefore is limited in clinical application …
The continuum of disrupted metabolic tempo, mitochondrial substrate congestion, and metabolic gridlock toward the development of non-communicable diseases
T Tippairote, G Bjørklund… - Critical Reviews in Food …, 2022 - Taylor & Francis
Non-communicable diseases (NCD) are the slow-motion disasters with imminent global
health care burden. The current dietary management for NCD is dominated by the calorie …
health care burden. The current dietary management for NCD is dominated by the calorie …
Assembly and symmetry of the fungal E3BP-containing core of the Pyruvate Dehydrogenase Complex
The pyruvate dehydrogenase complex (PDC) is a central component of all aerobic
respiration, connecting glycolysis to mitochondrial oxidation of pyruvate. Despite its central …
respiration, connecting glycolysis to mitochondrial oxidation of pyruvate. Despite its central …