Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits

M Peiseler, R Schwabe, J Hampe, P Kubes… - Journal of …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …

Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy

L Yang, Z Chu, M Liu, Q Zou, J Li, Q Liu… - Journal of hematology & …, 2023 - Springer
Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …

Autophagy in liver diseases: a review

H Qian, X Chao, J Williams, S Fulte, T Li, L Yang… - Molecular aspects of …, 2021 - Elsevier
The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis

S Kumar, Q Duan, R Wu, EN Harris, Q Su - Advanced drug delivery reviews, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease that encompasses a
spectrum of pathological conditions, ranging from simple steatosis (NAFL), nonalcoholic …

The Role of Macrophages in Staphylococcus aureus Infection

GR Pidwill, JF Gibson, J Cole, SA Renshaw… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is a member of the human commensal microflora that exists,
apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it …

PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets

H Chen, H Tan, J Wan, Y Zeng, J Wang… - Pharmacology & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …

[HTML][HTML] Nanoparticle biodistribution coefficients: A quantitative approach for understanding the tissue distribution of nanoparticles

M Kumar, P Kulkarni, S Liu, N Chemuturi… - Advanced Drug Delivery …, 2023 - Elsevier
The objective of this manuscript is to provide quantitative insights into the tissue distribution
of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 …

Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity

M Sakai, TD Troutman, JS Seidman, Z Ouyang… - Immunity, 2019 - cell.com
Tissue environment plays a powerful role in establishing and maintaining the distinct
phenotypes of resident macrophages, but the underlying molecular mechanisms remain …

Tumor immune microenvironment and immunosuppressive therapy in hepatocellular carcinoma: a review

K Oura, A Morishita, J Tani, T Masaki - International journal of molecular …, 2021 - mdpi.com
Liver cancer has the fourth highest mortality rate of all cancers worldwide, with
hepatocellular carcinoma (HCC) being the most prevalent subtype. Despite great advances …