Osteoporosis (OP) is a disease that weakens bones and has a high morbidity rate
worldwide, which is prevalent among the elderly, particularly, women of postmenopausal …

Early detection of inflammatory mediators including C-reactive protein (CRP) is of great
diagnostic importance in many human diseases. CRP elevates very fast in conditions such …

Several biomarkers of healthy aging have been proposed in recent years, including the
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …

Epigenetic ageing, ie, age‐associated changes in DNA methylation patterns, is a sensitive
marker of biological ageing, a major determinant of morbidity and functional decline. We …

Osteoporosis (OP) is a common skeletal disease involving low bone mineral density (BMD)
that often leads to fragility fracture, and its development is affected by multiple cellular …

Diabetes mellitus is a main risk factor for periodontitis, but until now, the underlying
molecular mechanisms remain unclear. Diabetes can increase the pathogenicity of the …

Stress is associated with various epigenetic changes. Some stress-induced epigenetic
changes are highly dynamic, whereas others are associated with lasting marks on the …

The aging process is driven by multiple mechanisms that lead to changes in energy
production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality …

Abstract The World Health Organization predicts that by 2050, 2.1 billion people worldwide
will be over 60 years old, a drastic increase from only 1 billion in 2019. Considering these …

Aging is a complex process that is not well understood but involves finite changes at the
genetic and epigenetic level. Physical activity is a well-documented modulator of the …