[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering

JR Tribble, F Hui, H Quintero, S El Hajji, K Bell… - Molecular aspects of …, 2023 - Elsevier
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances

VB Gupta, N Chitranshi, J den Haan, M Mirzaei… - Progress in retinal and …, 2021 - Elsevier
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …

Neuroserpin gene therapy inhibits retinal ganglion cell apoptosis and promotes functional preservation in glaucoma

N Chitranshi, R Rajput, A Godinez, K Pushpitha… - Molecular Therapy, 2023 - cell.com
Our research has proven that the inhibitory activity of the serine protease inhibitor
neuroserpin (NS) is impaired because of its oxidation deactivation in glaucoma. Using …

Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects

A Boccaccini, D Cavaterra, C Carnevale… - Molecular Aspects of …, 2023 - Elsevier
In the last years, neuroprotective therapies have attracted the researcher interests as
modern and challenging approach for the treatment of neurodegenerative diseases, aimed …

Brain-derived neurotrophic factor-mediated neuroprotection in glaucoma: a review of current state of the art

L Lambuk, MA Mohd Lazaldin, S Ahmad… - Frontiers in …, 2022 - frontiersin.org
Retinal ganglion cells (RGCs) are neurons of the visual system that are responsible for
transmitting signals from the retina to the brain via the optic nerve. Glaucoma is an optic …

Natural products: evidence for neuroprotection to be exploited in glaucoma

A Adornetto, L Rombolà, LA Morrone, C Nucci… - Nutrients, 2020 - mdpi.com
Glaucoma, a leading cause of irreversible blindness worldwide, is an optic neuropathy
characterized by the progressive death of retinal ganglion cells (RGCs). Elevated intraocular …

[HTML][HTML] Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN (E50K) human stem cell-derived retinal ganglion cells

C Gomes, KB VanderWall, Y Pan, X Lu, SS Lavekar… - Stem cell reports, 2022 - cell.com
Although the degeneration of retinal ganglion cells (RGCs) is a primary characteristic of
glaucoma, astrocytes also contribute to their neurodegeneration in disease states. Although …

Searching for the antioxidant, anti-inflammatory, and neuroprotective potential of natural food and nutritional supplements for ocular health in the mediterranean …

M Valero-Vello, C Peris-Martínez, JJ García-Medina… - Foods, 2021 - mdpi.com
Adherence to a healthy diet offers a valuable intervention to compete against the increasing
cases of ocular diseases worldwide, such as dry eye disorders, myopia progression …

Anti-inflammatory effects of siponimod in a mouse model of excitotoxicity-induced retinal injury

D Basavarajappa, V Gupta, N Chitranshi… - Molecular …, 2023 - Springer
Glaucoma is a leading cause of permanent blindness worldwide and is characterized by
neurodegeneration linked to progressive retinal ganglion cell (RGC) death, axonal damage …

Targeting diet and exercise for neuroprotection and neurorecovery in glaucoma

JR Tribble, F Hui, M Jöe, K Bell, V Chrysostomou… - Cells, 2021 - mdpi.com
Glaucoma is a leading cause of blindness worldwide. In glaucoma, a progressive
dysfunction and death of retinal ganglion cells occurs, eliminating transfer of visual …