The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in
tumor immunology research because ICT was discovered through basic studies of immune …

The sequencing of complete genomes provides a list that includes the proteins responsible
for cellular regulation. However, this does not immediately reveal what these proteins do …

Most autosomal genetic causes of childhood-onset hypogammaglobulinemia are currently
not well understood. Most affected individuals are simplex cases, but both autosomal …

Although CHS is a rare disease, the Chediak-like family of proteins is providing insight into
the regulation of vesicle trafficking. Understanding the basic mechanisms that govern vesicle …

Cell-cycle events are controlled by cyclin-dependent kinases (CDKs), whose periodic
activation is driven by cyclins. Different cyclins promote distinct cell-cycle events, but the …

BEACH (named after 'Beige and Chediak‐Higashi') is a conserved∼ 280 residue domain,
present in nine human BEACH domain containing proteins (BDCPs). Most BDCPs are large …

Gray platelet syndrome (GPS) is a predominantly recessive platelet disorder that is
characterized by mild thrombocytopenia with large platelets and a paucity of α-granules; …

Phosphatidylinositol-3-phosphate [PtdIns (3) P] regulates endocytic and autophagic
membrane traffic. In order to understand the downstream effects of PtdIns (3) P in these …

The granule‐dependent cytotoxic activity of lymphocytes plays a critical role in the defense
against virally infected cells and tumor cells. The importance of this cytotoxic pathway in …

The initial reports on pleckstrin homology (PH) domains almost 20years ago described them
as sequence feature of proteins involved in signal transduction processes. Investigated at …