The sphingolipid family of lipids modulate several cellular processes, including proliferation,
cell cycle regulation, inflammatory signaling pathways, and cell death. Several members of …

The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and
ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular …

The pathological increase in the levels of reactive oxygen species (ROS) in the retinal
pigment epithelium (RPE), is implicated in the development of age-related macular …

Quercetin is a flavonoid polyphenolic compound present in fruits and vegetables that has
proven anti-inflammatory activity. The goal of the present investigation was to investigate the …

Some experimental and clinical studies have been conducted for the usage of
chemotherapeutic drugs encapsulated into nanoparticles (NPs). However, no study has …

This study aims to explore the effects of exosomes, secreted by retinal pigment epithelial
(RPE) cells under oxidative stress (OS), on apoptosis and inflammation of normal RPE cells …

Abstract Aims: Circulating microparticles (MPs) from metabolic syndrome patients and those
generated from apoptotic T cells induce endothelial dysfunction; however, the molecular and …

The importance of sapienic acid (6c-16: 1), a monounsaturated fatty acid of the n-10 family
formed from palmitic acid by delta-6 desaturase, and of its metabolism to 8c-18: 1 and …

Inflammation in the retinal pigment epithelium is an important contributor to the
pathogenesis of age‑related macular degeneration. Wogonin is a flavonoid isolated from the …

Background We aimed to determine sphingolipid levels and examine apoptotic pathways in
human retinal pigment epithelial cells (ARPE-19) undergoing endoplasmic reticulum (ER) …