Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …

I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Despite the success of the BNT162b2 mRNA vaccine, the immunological mechanisms that
underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive …

Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …

One of the most significant challenges of inflammatory bowel disease (IBD) research is to
understand how alterations in the symbiotic relationship between the genetic composition of …

The cardinal stages of macroautophagy are driven by core autophagy‐related (ATG)
proteins, whose ablation largely abolishes intracellular turnover. Disrupting ATG genes is …

The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to
manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands …

While inbred mice have informed most of what we know about the immune system in the
modern era, they have clear limitations with respect to their ability to be informative …