Glioblastoma immunotherapy: A systematic review of the present strategies and prospects for advancements

E Agosti, M Zeppieri, L De Maria, C Tedeschi… - International Journal of …, 2023 - mdpi.com
Glioblastoma (GBM) is characterized by aggressive growth and high rates of recurrence.
Despite the advancements in conventional therapies, the prognosis for GBM patients …

Harnessing type I interferon-mediated immunity to target malignant brain tumors

J Lim, I Kang, J La, KB Ku, BH Kang, Y Kim… - Frontiers in …, 2023 - frontiersin.org
Type I interferons have long been appreciated as a cytokine family that regulates antiviral
immunity. Recently, their role in eliciting antitumor immune responses has gained increasing …

The Use of Targeted Cytokines as Cancer Therapeutics in Glioblastoma

M Sooreshjani, S Tripathi, C Dussold, H Najem… - Cancers, 2023 - mdpi.com
Simple Summary Despite multi-modal treatment consisting of surgery, chemotherapy, and
radiation, glioblastoma inevitably recurs due to its diffuse infiltrative nature. Anti-tumor …

[HTML][HTML] Design of Experiments to Tailor the Potential of BSA-Coated Peptide Nanocomplexes for Temozolomide/p53 Gene Co-Delivery

I Afonso, AR Neves, D Eusébio, T Albuquerque… - Pharmaceutics, 2024 - mdpi.com
Background: Gene therapy can be viewed as a promising/valuable therapeutic approach
directed to cancer treatment, including glioblastoma. Concretely, the combination of gene …

Targeting innate immunity in glioma therapy

AG Gillard, DH Shin, LA Hampton… - International journal of …, 2024 - mdpi.com
Currently, there is a lack of effective therapies for the majority of glioblastomas (GBMs), the
most common and malignant primary brain tumor. While immunotherapies have shown …

Advancements and challenges: immunotherapy therapy in high-grade glioma-a meta-analysis of randomized clinical trials

LB Palavani, LP Mitre, R Camerotte… - Journal of Neuro …, 2024 - Springer
Background High-grade gliomas (HGG) are the most aggressive primary brain tumors with
poor prognoses despite conventional treatments. Immunotherapy has emerged as a …

Single‐cell transcriptomics reveals IRF7 regulation of the tumor microenvironment in isocitrate dehydrogenase wild‐type glioma

J Li, S Long, Z Yang, W Wei, S Yu, Q Liu, X Hui… - MedComm, 2024 - Wiley Online Library
Mutations in isocitrate dehydrogenase (IDH) are important markers of glioma prognosis.
However, few studies have examined the gene expression regulatory network (GRN) in IDH …

Radiotherapy and radio‐sensitization in H3K27M‐mutated diffuse midline gliomas

C Liu, S Kuang, L Wu, Q Cheng, X Gong… - CNS Neuroscience …, 2023 - Wiley Online Library
Abstract Background H3 K27M mutated diffuse midline gliomas (DMGs) are extremely
aggressive and the leading cause of cancer‐related deaths in pediatric brain tumors with 5 …

[HTML][HTML] Emerging trends and thematic evolution of immunotherapy for glioma based on the top 100 cited articles

Y Zhou, M Liu, X Huang, Z Liu, Y Sun, M Wang… - Frontiers in …, 2024 - frontiersin.org
Purpose This study aims to depict the scientific advancements in immunotherapy for glioma
by analyzing the top 100 most frequently cited articles over the past 20 years. Methods The …

Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas

R Onciul, FM Brehar, C Toader… - Current Issues in …, 2024 - mdpi.com
Gliomas constitute a diverse and complex array of tumors within the central nervous system
(CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic …