Hypoxia in solid tumors is an important predictor of poor clinical outcome to radiotherapy.
Both physicochemical and biological processes contribute to a reduced sensitivity of hypoxic …

In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …

Simple Summary Hypoxia is a common feature of solid tumors and associated with poor
outcome in most cancer types and treatment modalities, including radiotherapy …

ABSTRACT ATM and ATR signaling pathways are well conserved throughout evolution and
are central to the maintenance of genome integrity. Although the role of both ATM and ATR …

Glioblastoma (GBM) is a lethal primary brain tumor characterized by treatment resistance
and inevitable tumor recurrence, both of which are driven by a subpopulation of GBM cancer …

Under hypoxic conditions, tumor cells undergo a series of adaptations that promote
evolution of a more aggressive tumor phenotype including the activation of DNA damage …

Hypoxia was identified as a microenvironmental component of solid tumours over 60 years
ago and was immediately recognised as a potential barrier to therapy through the reliance of …

The DNA damage response (DDR) occurs in the context of chromatin, and architectural
features of chromatin have been implicated in DNA damage signaling and repair. Whereas …

Radioresistance is regarded as the main barrier to effective radiotherapy in lung cancer.
However, the underlying mechanisms of radioresistance remain elusive. Here, we show that …

DNA replication is one of the fundamental biological processes in which dysregulation can
cause genome instability. This instability is one of the hallmarks of cancer and confers …