The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

Since the initial reporting of the successful reversal of hyperglycemia through the
transplantation of pancreatic islets, significant research efforts have been conducted in …

Endocrine pancreatic β cells require endothelial signals for their differentiation and function.
However, the molecular basis for such signals remains unknown. Here, we show that β cells …

To determine the site and mechanism of suppression by regulatory T (Treg) cells, we
investigated their migration and function in an islet allograft model. Treg cells first migrated …

To investigate molecular mechanisms controlling islet vascularization and revascularization
after transplantation, we examined pancreatic expression of three families of angiogenic …

Islet transplantation is a promising alternative therapy for insulin-dependent patients, with
the potential to eliminate life-threatening hypoglycemic episodes and secondary …

Type 1 diabetes (T1DM) affects one in every 400 children and adolescents in the US. Due to
the limitations of exogenous insulin therapy and whole pancreas transplantation, pancreatic …

The transplantation of pancreatic islets, following the Edmonton Protocol, is a promising
treatment for type I diabetics. However, the need for multiple donors to achieve insulin …

Islet transplantation may be used to treat type I diabetes. Despite tremendous progress in
islet isolation, culture, and preservation, the clinical use of this modality of treatment is …

The growth of both tumors and nonneoplastic tissues may be influenced by signals from the
vascular endothelium. In the present investigation we show that purified proliferating …