Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

Despite being banned from production for decades, polychlorinated biphenyls (PCBs)
continue to pose a significant risk to human health. This is due to not only the continued …

Systematic consideration of scientific support is a critical element in developing and,
ultimately, using adverse outcome pathways (AOPs) for various regulatory applications …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

The remarkable advances coming about through nanotechnology promise to revolutionize
many aspects of modern life; however, these advances come with a responsibility for due …

In this project we set up a human cell‐based DNTin vitro testing strategy that is based on test
methods with high readiness and data generated therefrom. The methods underwent afit‐for …

Currently, the identification of chemicals that have the potential to induce developmental
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …

Growing concern suggests that some chemicals exert (developmental) neurotoxicity (DNT
and NT) and are linked to the increase in incidence of autism, attention deficit and …

Background In light of the vulnerability of the developing brain, mixture risk assessment
(MRA) for the evaluation of developmental neurotoxicity (DNT) should be implemented …