Chronic wounds are defined as wounds that fail to proceed through the normal phases of
wound healing in an orderly and timely manner. The most common and inevitable …

During the course of malignant cancer progression, neoplastic cells undergo dynamic and
reversible transitions between multiple phenotypic states, the extremes of which are defined …

The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …

Aberrant gene function and altered patterns of gene expression are key features of cancer.
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …

T cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy
driven mainly by oncogenic activation of NOTCH1 signaling. In this study we report the …

Formation of long term memory begins with the activation of many disparate signaling
pathways that ultimately impinge on the cellular mechanisms regulating gene expression …

The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential
for embryonic development and stem cell renewal and are commonly deregulated in cancer …

Epigenetic chromatin marks restrict the ability of differentiated cells to change gene
expression programs in response to environmental cues and to transdifferentiate. Polycomb …

It is more evident now than ever that nucleosomes can transmit epigenetic information from
one cell generation to the next. It has been demonstrated during the past decade that the …

On the histone H3 tail, Lys 9 and Lys 27 are both methylation sites associated with
epigenetic repression, and reside within a highly related sequence motif ARKS. Here we …