Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This
review will focus on these mechanisms, ie regulation of cyclin‐dependent kinases (CDK) by …

The paullones represent a novel class of small molecule cyclin-dependent kinase (CDK)
inhibitors. To investigate structure− activity relationships and to develop paullones with …

We have recently shown that curcumin induces apoptosis in prostate cancer cells through
Bax translocation to mitochondria and caspase activation, and enhances the therapeutic …

Inhibiting Cyclin-dependent kinase 2 (CDK2) has been established as a therapeutic strategy
for the treatment of many cancers. Accordingly, this study aimed at developing a new set of …

Development and growth of all organisms involves the faithful reproduction of cells and
requires that the genome be accurately replicated and equally partitioned between two …

We show that the recently discovered tumor suppressor pdcd4 represses the transcription of
the mitosis-promoting factor cyclin-dependent kinase (CDK) 1/cdc2 via upregulation of …

There is enormous potential for the discovery of innovative cancer drugs with improved
efficacy and selectivity for the third millennium. In this review we show how novel …

The cell-division cycle is a tightly controlled process that is regulated by the cyclin/CDK
family of protein kinase complexes. Stringent control of this process is essential to ensure …

Deregulation of cyclin-dependent kinase 2 (CDK2) and its activating partners, cyclins A and
E, is associated with the pathogenesis of a myriad of human cancers and with resistance to …