Specialized pro-resolving mediators (SPMs) are enzymatically derived from essential fatty
acids and have important roles in orchestrating the resolution of tissue inflammation—that is …

Lipid droplets (LDs) contribute to key pathways important for the physiology and
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …

Astrocytes actively participate in synaptic integration by releasing transmitter (glutamate) via
a calcium-regulated, exocytosis-like process. Here we show that this process follows …

Abstract Human immunodeficiency virus-1 (HIV-1) can induce dementia with alarming
occurrence worldwide. The mechanism remains poorly understood, but discovery in brain of …

This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

Macrophage/microglia (M∅) are the principal immune cells in the central nervous system
(CNS) concomitant with inflammatory brain disease and play a significant role in the host …

The resolution of the inflammatory response is highly regulated by the timely biosynthesis of
a number of endogenous lipid mediators. Among these, lipoxins (LX) and their 15-epimers …

Lipoxins are bioactive eicosanoids that are immunomodulators. In human myeloid cells,
lipoxin (LX) A4 actions are mediated by interaction with a G protein–coupled receptor. To …

Infection with the human immunodeficiency virus-1 (HIV-1) can induce severe and
debilitating neurological problems that include behavioral abnormalities, motor dysfunction …

Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a
biologically active phospholipid mediator. Although PAF was initially recognized for its …