A review: Pharmacological aspects of metal based 1, 2, 4-triazole derived Schiff bases

W Zafar, SH Sumrra, ZH Chohan - European journal of medicinal chemistry, 2021 - Elsevier
Clinical reports have highlighted the radical increase of antibiotic resistance. As a result,
multidrug resistance has emerged as a serious threat to human health. Many organic …

A review on the antimicrobial assessment of triazole-azomethine functionalized frameworks incorporating transition metals

W Zafar, M Ashfaq, SH Sumrra - Journal of Molecular Structure, 2023 - Elsevier
Antimicrobial resistance is a growing threat to global public health that calls for innovative
strategies to develop new methods of action against resistance to emerging infectious …

Metal complexes, an untapped source of antibiotic potential?

A Frei - Antibiotics, 2020 - mdpi.com
With the widespread rise of antimicrobial resistance, most traditional sources for new drug
compounds have been explored intensively for new classes of antibiotics. Meanwhile, metal …

Machine learning-powered antibiotics phenotypic drug discovery

S Zoffmann, M Vercruysse, F Benmansour, A Maunz… - Scientific reports, 2019 - nature.com
Identification of novel antibiotics remains a major challenge for drug discovery. The present
study explores use of phenotypic readouts beyond classical antibacterial growth inhibition …

Designing, physiochemical confirmation, evaluation of biological and in-silico potential of Triorganotin (IV) complexes

B Hanifa, M Sirajuddin, ERT Tiekink, I Khan… - Journal of Molecular …, 2022 - Elsevier
Abstract FTIR, NMR, CHN and single crystal X-ray crystallography were used to validate a
series of three new triorganotin (IV) carboxylate complexes, R 3 Sn (L) for R= Methyl (1), n …

Polishing the tarnished silver bullet: the quest for new antibiotics

MAT Blaskovich, MS Butler… - Essays in biochemistry, 2017 - portlandpress.com
We are facing a potential catastrophe of untreatable bacterial infections, driven by the
inexorable rise of extensively drug-resistant bacteria, coupled with a market failure of …

Three isomeric 4-[(n-bromophenyl) carbamoyl] butanoic acids (n= 2, 3 and 4) as DNA intercalator: Synthesis, physicochemical characterization, antimicrobial activity …

B Hanifa, M Sirajuddin, M Kubicki… - Journal of Molecular …, 2022 - Elsevier
A series of three isomeric 4-[(n-bromophenyl) carbamoyl] butanoic acids (n= 2, 3 and 4)
were synthesized and their structures were confirmed by FTIR, NMR, MS, micro elemental …

Synthesis and Evaluation on the Fungicidal Activity of S-Alkyl Substituted Thioglycolurils

EE Vinogradova, AL Alekseenko, SV Popkov… - International Journal of …, 2023 - mdpi.com
A series of S-alkyl substituted thioglycolurils was prepared through the alkylation of
corresponding thioglycolurils with halogenoalkanes and tested for their fungicidal activity …

Synthesis, spectral characterisation, biocidal investigation, in-silico and molecular docking studies of 4-[(2-chloro-4-methylphenyl)carbamoyl]butanoic acid derived …

B Hanifa, N Bibi, M Sirajuddin, ERT Tiekink… - Journal of …, 2024 - Taylor & Francis
Three triorganotin (IV) compounds, R3Sn (L), with R= CH3 (1), n-C4H9 (2) and C6H5 (3),
and LH= 4-[(2-chloro-4-methylphenyl) carbamoyl] butanoic acid, were prepared and …

Antimicrobial and antifungal activities of Terpene-Derived Palladium complexes

O Zalevskaya, Y Gur'eva, A Kutchin, KA Hansford - Antibiotics, 2020 - mdpi.com
In an era of multidrug-resistant bacterial infections overshadowed by a lack of innovation in
the antimicrobial drug development pipeline, there has been a resurgence in …