The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of
solid tumours that plays a crucial role in shaping their progression. Many desmoplastic …

Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

In recent years, the biological role of changes in physical factors in carcinogenesis and
progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is …

Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression.
Recent studies have shown that matrix stiffening is caused by the accumulation, contraction …

Tissues consist of cells and their surrounding extracellular matrix (ECM). Cell–ECM
interactions play crucial roles in embryonic development, differentiation, tissue remodeling …

Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs
is limited by incomplete understanding of the biological mechanisms that drive metastasis …

The extracellular matrix (ECM) is a complex assembly of hundreds of proteins forming the
architectural scaffold of multicellular organisms. In addition to its structural role, the ECM …